The story begins two years from where the previous film ends, and Peter Parker is finding his double life increasingly difficult. Precariously struggling to balance his crime-fighting duties with the demands of his normal life, Peter often finds his personal life taking a back seat. He loses a job, faces financial difficulties, and struggles to maintain his physics studies. Moreover, he has become estranged from both love interest Mary Jane and best friend Harry Osborn, and Aunt May is threatened with foreclosure.
Harry, now head of Oscorp's research division, has invested in the research of brilliant scientist Otto Octavius, Peter's idol. To perform a sustained fusion experiment, Octavius has developed a set of artificially intelligent mechanical arms, which are impervious to heat and magnetism. Though the experiment overloads and becomes unstable, Dr. Octavius refuses to halt it, with devastating results: his wife is killed; the neural inhibitor chip which enabled him to control the arms is destroyed; and the arms are fused to his spine. Uncontrolled, the tentacles begin to influence Octavius' mind, playing on his vanity and ego, and he decides he must complete his experiment at any cost. J. Jonah Jameson names him Doctor Octopus or "Doc Ock." Doc Ock attempts to rob a bank where Peter Parker and his Aunt May happen to be present. After a short glitch in his powers, Spider-Man manages to take back most of the stolen money, but Doc Ock takes Aunt May as a hostage. When Spider-Man rescues her, she revises her former opinion of him and realizes that he is a hero.
Peter Parker gives up being Spider-Man
Spider-Man battles Doctor Octopus atop a subway train
Spider-Man manages to stop the train before it can plunge over the end of the track, but at great physical exertion. Weak, he is captured by Doctor Octopus and delivered to Harry Osborn. Harry unmasks Spider-Man and is stunned to discover that his sworn enemy is also his best friend. Peter awakens and convinces Harry to reveal Octavius' whereabouts so he can rescue Mary Jane. Spider-Man finds Doctor Octavius in an abandoned warehouse on a waterfront pier, where he's restarted his fusion experiment. After battling with Doc Ock, Spider-Man manages to stun the villain with an electric shock. Peter then reveals his true identity to Octavius and pleads with him to stop the machine. Returned to his senses and determined to end his doomsday experiment before it causes more harm, Octavius uses his mechanical arms to collapse the floor of the building, successfully drowning the device at the cost of his own life. Mary Jane sees Peter without his mask on, but Peter tells her they can never be together, as he will always have enemies.
Across town, Harry has visions of his father, the late Norman Osborn, in a hanging mirror. The illusion demands that his son kill Peter Parker to avenge his death. Harry refuses and hurls a dagger at the mirror, shattering it and revealing a secret room, containing the Green Goblin's war gear. At the end of the film, Mary Jane leaves her wedding and finds Peter in his apartment, telling him that she has decided to be with him — despite the risks. She persuades Peter to finally let her in while accepting the need of his vows by letting him respond to a sudden call for help.
Cast
- Tobey Maguire as Peter Parker / Spider-Man: A superhero, a college physics student and photographer for the Daily Bugle. Juggling these separate lives means he briefly gives up his responsibilities as a superhero in a moment of adversity. When Maguire signed on to portray Spider-Man in 2000, he was given a three film contract. While filming Seabiscuit in late 2002, Maguire suffered injuries to his back and Sony was faced with the possibility of recasting their lead. Jake Gyllenhaal was negotiated with to replace Maguire, who at the time was dating Kirsten Dunst, who portrayed Mary Jane Watson. However, Maguire recovered and was able to reprise his role, with a salary of $17 million.
- Alfred Molina as Dr. Otto Octavius / Doctor Octopus: A scientist and hero of Peter's who goes insane after his failure to create a self-sustaining fusion reaction. Octavius is bonded with his handling equipment, four artificially intelligent mechanical tentacles. These convince him to carry on his dangerous experiments no matter the cost, in memory of his wife who was killed in the fusion accident. Molina was cast as Octavius in February 2003 and immediately began physical training for the role. Raimi had been impressed by his performance in Frida and also felt he had the physicality. Molina only briefly discussed the role and was not aware that he was a strong contender for the role, and was excited, being a big fan of Marvel Comics. Although he wasn't familiar with Doc Ock, Molina found one element of the comics that he wanted to maintain, and that was the character's cruel, sardonic sense of humor.
- Kirsten Dunst as Mary Jane Watson: The woman Peter has loved since he was a child, yet he gave up the chance of being with her due to his obligations as a superhero. Since then, she has become a successful Broadway actress and model, and becomes engaged to John Jameson. She is angry due to Peter's failure to watch her performance in The Importance of Being Earnest, when everybody else close to her, and even her abusive father, have seen it.
- James Franco as Harry Osborn: Harry Osborn has taken his father's position as head of Oscorp. He supplies Octavius with tritium for the fusion experiment, but when it fails, Harry falls into alcoholism and a desire to kill Spider-Man, whom he believes killed his father. Harry also becomes angry at Peter, believing he will not tell him who Spider-Man is, being the supplier of his photographs to the Daily Bugle.
- J.K. Simmons as J. Jonah Jameson: J. Jonah Jameson is the miserly chief of the Daily Bugle who carries a personal vendetta against Spider-Man, whom he considers a criminal. When Spider-Man temporarily gives up, Jameson also begins to reconsider his opinion of the superhero.
- Rosemary Harris as May Parker: May Parker is the loving aunt to Peter, a widow of Ben. She blames herself for his murder, but is still unaware of the circumstances surrounding it.
- Daniel Gillies as John Jameson: The son of J. Jonah Jameson, fiancé of Mary Jane and a national hero.
- Dylan Baker as Dr. Curt Connors: Dr. Curt Connors is one of Peter's physics professors at college, who reminds him to get his work done. He is a colleague of Octavius.
- Donna Murphy as Rosalie Octavius: Rosalie Octavius is the dedicated wife and assistant of Otto Octavius.
- Willem Dafoe as Norman Osborn: Norman returns as a hallucination of his son Harry. Dafoe came up with the idea during promotion for Spider-Man, which he compared to King Hamlet haunting his son to avenge him.
Bruce Campbell cameoed as an obnoxious usher who denies Peter access to Mary Jane's play when he is late, thus causing a rift in their relationship. Spider-Man's co-creator Stan Lee cameoed as a man on the street who saves a woman from falling debris during a battle between Spider-Man and Doc Ock. Evil Dead II co-writer Scott Spiegel appeared as a man who attempts to eat some pizza Spider-Man is delivering, only to have it webbed from his hands.
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